Yi danna shi a kan kwayoyin ƙasa?

Bayanin

Arthritis kuma zai buga daga wannan gaba na yaro. Bayanin da ke yi a cikin hanyar shirye, suna za'a taimakon samun rubutu da wani abubuwan side effects ya kamata. Shirya laser (light) low-level (LLLT) yana yanki mai tsarin da aka zo ne, domin tunani da aka gabatarwa masu rubutu suka yi a cikin arthritis. A cikin wannan rubutu na Arthritis Research & Therapy , Alves da mutane suna suke yi sabbanin modelin ratu na arthritis yayin wannan aiki papain, enzyme dai dai da aka yi shirye ta cartilage. Sabbanin LLLT 810-nm yana yi amfani da wannan modelin. Wannan shirya LLLT bayanin suna yi amfani da wannan sabbanin, suna saukar da takardun wannan aikinsa 24 kasarar ba. Laser power na jama'a yana so daidaitaka da laser power na kasa. Kuma, wannan sabbanin zai iya yi amfani da karfi ba.

Bayanin

A cikin wannan rubutu na Arthritis Research & Therapy , Alves da mutane [ 1] yana kula aikin preklinikar da aka yi shirin, suna jihar rayuwar zuciya na ratuwa daga alamun gida don hanyar rayuwar zuciya na near-infrared daga alamun gida don labarar samarun samfari a cikin modelin animal na osteoarthritis. Daga rubutu mai karfi 1 daga America suka yi samfari sabon rai'a na osteoarthritis daga rubutu mai karfi, ko suka yi wadannan hanyar sosai 80% daga rubutu mai karfi 75 [ 2]. Hanyar tsarinna ne biyu analgesics (acetaminophen), non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen wannan da diclofenac), ko COX2 inhibitors (Celebrex, Pfizer Inc., New York, NY, USA), amma hanyar sosai ne sosai risuƙa na side effects, mai tsabaron giɗi don NSAIDs ko myocardial infarction don COX2 inhibitors [ 3]. Low-level laser (light) therapy (LLLT) ne aikin sosai na farko da aka yi sosai don samfari da kasance da kasance, don hanyar samfari, ko don baya masu mauta da samfari da kasance daga alamun gida don kasance ko infarction [ 4]. Rayuwanci red or near-infrared aka yi sosai don cytochrome c yanki (unit IV dai dai mitochondrial respiratory chain), kawai zai yi matsayi mitochondrial respiration mai ATP production da kawai zai samu sabon gari daidai reactive oxygen species, nitric oxide, da cyclic AMP, yanzu zai saita masu amfani shugaban transcription factors [ 5]. Sabon gareshin studies zai iya samun rubutu anti-inflammatory effects dai dai LLLT da zai汇报 reductions ne dai dai inflammatory cell (neutrophils, macrophages, lymphocytes, da mast cells) infiltration dai dai multiple pathologies da zai汇报 reductions ne dai dai several inflammatory cytokines, wanda ILs da TNF-α. Sabon observers zai汇报 rubuta wannan wannan wannan biphasic dose response zai amfani LLLT, da wannan zaiƙwaye amsa wannan wannan increasing total energy ko rate of energy delivery (power density) zaiɓe counterproductive, zaiɗa wannan wannan benefit compared with lower doses dai dai LLLT [ 6]. LLLT ya ci gaba daga cikin klinikai a cikin osteoarthritis don shagari da suka yi, amma suna ne yanzu daidaitakawa. A cikin rubutu Cochrane [ 7] suka rapopada wannanwa da wannanwa mai tsara, amma tare da analishin da aka yi Alhaji Bjordal suka gabatar da 'rubutun Cochrane bai da kyauta bai da haka bai. Rubutun tambaya na hanyar tambayoyi mai aiki da wannan daiyarkuwa mai samfili, wadannan aiki mai samfili mai samar daidai, ina rayuwar subguruppiya suka bukatar wannan da wannan da aka yi mai kyauta daidai a cikin LLLT active don osteoarthritis’ [ 8]. Wannan tsallarin littattafin suka gabatar da kuma kasuwanci mai aiki ga ranar animali, klinikai trial, da rubutun systematiƙi suka yi ba LLLT za'a sami mai kyauta daidai a cikin aiki.

Alves da daiyar sauka [ 1] suna masu kewaye na gida a cikin modelin kwaye na dadi osteoarthritis daya da keƙe, yanzu da enzyme proteolytic papain an yi shirin a cikin tsaki na rat turjiya, ana soje karatilajin, kuma ana soje watsarki. Tsakoyin suka samu rubutu ɗaya da energy 4 J a cikin laser 808-nm a cikin wannan lokaci mai watsarƙe da wani ya kamata da 50 ko 100 mW, kuma rats suka fada hanyar 24 sabuwar. Wannan matsayin suka same amfani da bayan gabatarwa na watsarki a cikin fluid ga washing synovial daya da power levels, kuma gabatarwa mai macrophages ya kamata da 50-mW power level. Gabatarwa na IL-1β da IL-6 mRNA suka same, da 50 mW ya kamata da 100 mW, kuma gabatarwa na TNF-α ya kamata da 100 mW. Matsayin suka taimakonin da wannan lokacin mai watsarƙe da aka yi sosai a cikin samun rayuwar ɗaya a cikin half power ya kamata da effect na 50-mW laser application, kuma wannan ya same da study daya mai wuce ne zymosan-induced arthritis a cikin turjiyar rat [ 9] da ke kai wanda shine aikinƙasa mai shirye a cikin yanzu. Sabon hanyarwa na wannan gurin [ 10] ya fi sanya suna aikinƙasa LLLT a cikin model mai samun shine, shine masu aiki daga sabon masu rubutu da kwayoyin masu gabatarwa suka yi daga masu gabatarwa a cikin abubuwan tsari. Wannan hanyarwa suke yi tambaya mai karfi don zama LLLT (mai amfani da laser near-infrared mai amfani da gabatarwa talakaɗa required daga joints) don aiki don osteoarthritis. Mai amfani da wannan, ya kamata ne za'a iya tambayi wannan hanyarwa ne sabon model talakawa, ba sabon hanyarwa clinician daga magana talakawar kasance, da wannan hanyarwa suka yi daga sabon masu gabatarwa suka yi don zama manufa LLLT don osteoarthritis. Don mutum mai amfani da wannan, LLLT ya kamata ne shine masu aiki daga sabon masu gabatarwa suka yi daga masu rubutu da kwayoyin masu gabatarwa suka yi daga masu rubutu da kwayoyin masu gabatarwa suka yi daga masu rubutu da kwayoyin masu gabatarwa suka yi daga masu rubutu da kwayoyin masu gabatarwa [ 11].

Kashin Ruwan

IL: Interleukin; LLLT: Low-level laser (light) therapy; NSAID: Non-steroidal anti-inflammatory drug; TNF-α: Tumor necrosis factor-alpha.

Sabon hanyarwa

Ina gani aikin da kuma ya kirshi mai cikakken mutum.

Bincike hanyar Alves et al . http://arthritis-research.com/content/15/5/R116

Bayanin samunaiwa

Samunin labaraiya na aikin suka so daidaitashe da National Institutes of Health grant R01AI050875.

Rukune