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I na-achọ mkpụrụ ọgbuide n'aka ndebe akwụkwọ?

Apr 15, 2025

I na-achọ mkpụrụ ọgbuide n'aka ndebe akwụkwọ?

Na"Hamblin MR"[Author]
PMCID: PMC3978432 PMID: 24286607

Aka ncheta

Mkpụrụ ọgbuide na-enye mgbe e nyere ụmụnna. Akwụkwo ziri ike gbasara na amani ọnụọgụgụ na-anịghị mmepụta na-ezighi nnukwu. Low-level laser (akwụkwọ) therapy (LLLT) bụ obere ahụ na-anịghị mmepụta na na-eme ihe nke mmepụta n'aka ndebe akwụkwọ. N'ezie ahihịa na Arthritis Research & Therapy , Alves na ọdịnala ha ga-ewu mmụnanya ndị eze n'ime mmiri ọchịchịrịta ala aga akwụkwọ papain ga-ezere ikwu ọkara na-agba mgbe si test 810-nm LLLT. Eziokwu ozi na LLLT jiri ihe icheche maka nnukwu icheche na nnukwu icheche 24 ọsọ nke afọ. Nnukwu ite laser nwere ike iche na-eme na nnukwu laser nke ukwu. Ma, ka anya n'ihi na ejikwe mere ka mkpisi mkpa gbasara otu otu.

Aka ncheta

N'ime akwụkwọ nke Arthritis Research & Therapy , Alves na ọdịnala ha [ ]汇报了一项有趣的临床前研究，表明将红外光应用于大鼠膝关节在骨关节炎动物模型中对关节炎症有显著益处。在美国，每两个人中就有一个在其一生中的某个时候会经历某种形式的骨关节炎，而在75岁以上的人群中，其发病率为80% [ ]. Aka nwere ike ịgbachi ndụ (acetaminophen), mmiri nchekwa na-eme mmiri nnukwu (NSAIDs) (ibuprofen na diclofenac), na COX2 inhibitors (Celebrex, Pfizer Inc., New York, NY, USA), ma obere ha nwere ọgwụ iche n'ezie, site gastrointestinal bleeding na-eme heart attack n'aka COX2 inhibitors [ ]. Low-level laser (light) therapy (LLLT) bụ nweta nwere ike na-eme na-agba n'ime ọzọr ọnwa ndụ nke akwụkwọ gara aga, nke ịkpamgoshi nke ndụ na-eme healing, na ịchọma nke mara ọnwa ndụ nke agha ọkara ma na infarction [ ]. Akuku red ma near-infrared nwere ike na-eme n'akpa cytochrome c na-eme mmiri nnukwu (unit IV nke mitochondrial respiratory chain), na-akwụcha ndụ mitochondria na ATP production na na-eme signaling pathways maka reactive oxygen species, nitric oxide, na cyclic AMP, na-akwụcha nke nwere ike na-eme na-eme several transcription factors [ ]. Nkārịrị ọdịnaya nke mmiri na-akwado ihe iche-iche anti-inflammatory effects of LLLT na-eme ka ọnwa ndụ ikike (neutrophils, macrophages, lymphocytes, na mast cells) akpụra n'ime ọdịnaya na-enye na-eme ka ọnwa ndụ ikike nke iche-iche inflammatory cytokines, mara ILs na TNF-α. Ntụntụ ntụ na-eme ka ọ bụrụ na-aka biphasic dose response a na-eji LLLT, na ọ bụrụ na ime mkpa ọnụrụ ma ọ bụ na-eme mkpa ọnụrụ (power density) bụgwara eziokwu, na-enye aka ndị mmiri ndụ na-eme ka ndị ite mkpa ọnụrụ LLLT [ ]. LLLT na-eji ihe clinical n'osteooarthritis nke otu ọzọ maka ọ bụrụ na-anaghị eweta na-agha. Mma Cochrane review [ ] nwere ihe ezu na-akwado, anaobi akwukwo dịka biara na-eche Bjordal na ọdịnala gara a ka 'akwukwo Cochrane bụ nnọkọ na-anachịta. Anaobi na-abụghị mmiri na-inye ndị na-eme egwuregwu, na-anachịta na-enweghị ndị na-eme follow-up, na anali subgroup na-ekwu ihe nke akwukwo atụgharịa na ejikere na-eme LLLT maka osteoarthritis' [ ]. Ihe nwere ihe ezu na-akwado ahụ suggest na otu ndị na-adịghị mmasị kpataku nke mmalite na-anabere animal studies, clinical trials, na systematic reviews kwa LLLT maara ga-emechaa nke mmalite.

Alves na ọdịnala gara a [ ] nwere ike ọdịnala ndị na-ekwu modelụ ka osteoarthritis maara na-enye proteolytic enzyme papain na-akwụkwa maka nkpu ikuku rat, ndị na akwụkwa cartilage gbasara, maara na-enye inflammation. Nkpu ikuku ga-eme oge abụọ mmepụta 4 J energy n'aka laser 808-nm na-agbakwuru na-abịa na na-akpata na nkpu ikuku, na-eme na-abịa maka 50 ma 100 mW, na ndị rat ga-eje maka 24 ozi. Ntụntụ nwere ike ọdịnala ndị na-eme reduction n'ime inflammatory cells n'ume fluid n'asusu synovial washing na-abịa maka mmepụta power, maara na-enye reduction nke macrophages na-power level 50-mW. Reductions n'ime IL-1β na IL-6 mRNA were found, na 50 mW bụrụ na-eme better than 100 mW, maara na-enye bigger reduction nke TNF-α n'ime 100 mW. Ntụntụ na-eme hypothesis na oge illumination twice longer needed to deliver same energy at half the power bụrụ na-eme responsible for better effect of 50-mW laser application, na ihe bụrụ na-agbaa with study nke otu ha na-egosi zymosan-induced arthritis n'ikuku rat [ ] na-achọ bụụ kwụsịrị ndị iche ihe nwere ike ọgwụ abụghị. Nkērịtịta ndị ya [ ] ga-ezi okwu na LLLT n'aka njemaa na-abụghị modelu, zụtara angiogenesis na akwụkwọ ha maka squamous epithelium ma ọ bụrụ na ọnwa fibrosis n'aka n'okpuru. Ihe ha na-eme mkpisi ọzọ maka nsọ nkwerẹe LLLT (nweta laser near-infrared e nyere ihe nwere ike ọgwụ n'okpuru maka aka) kama ọgwụ mmadụ maka osteoarthritis. Ma ọ bụrụ, ka anya nwere ike na nkọwa na-ekwu ọzọ na modelu ụlọ mmeghị, ma ọ bụrụ na ọ bụ clinical study n'ụlọ ọha mmadụ, na nkwerẹe ọzọ na-akwado site si ihe mere LLLT n'aka osteoarthritis. N'afọ na ihe mere anti-inflammatory, LLLT ma na-eme mkpisi ọzọ maka ike ya nwere ike ịnanya ụmụ nke ọchịchị ụkpụrụ na-agba endogenous opioid receptors [ ].

Mgbakwunye

IL: Interleukin; LLLT: Low-level laser (light) therapy; NSAID: Non-steroidal anti-inflammatory drug; TNF-α: Tumor necrosis factor-alpha.

Nkọwa ọzọ

Ọdịnala nwere ike ịgbachi na enweghị ndabere mmiri.

Gba arụkwọ nke Alves et al . http://arthritis-research.com/content/15/5/R116

Ncheghezigha

Arụkwọ n'obodo ọdịnala gaa egwu National Institutes of Health R01AI050875.

Mkpakọrọ

  1. Alves AC, Vieira RP, Leal-Junior EC, Dos Santos SA, Ligeiro AP, Albertini R, Junior JA, de Carvalho PD. Ntụọta maka mkpụrụ okwuchie laser level low n'aka mkpụrụ ndabere mmiri na-ekwu ọgwụ na n'aka nkita ọkpara na macrophages n'ime akpa akpukpuru akwụkwọ. Arthritis Res Treat. 2013;15:R116. doi: 10.1186/ar4296.  [DOI ] [ Article ọ bụla PMC ] [ PubMed ] [ Google Scholar ]
  2. Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol. 2006;15:3–25. doi: 10.1016/j.berh.2005.09.007.  [DOI ] [ PubMed ] [ Google Scholar ]
  3. Cheng DS, Visco CJ. Pharmaceutical therapy for osteoarthritis. PM R. 2012;15:S82–S88. doi: 10.1016/j.pmrj.2012.02.009.  [DOI ] [ PubMed ] [ Google Scholar ]
  4. Chung H, Dai T, Sharma SK, Huang YY, Carroll JD, Hamblin MR. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng. 2012;15:516–533. doi: 10.1007/s10439-011-0454-7.  [DOI ] [ Article ọ bụla PMC ] [ PubMed ] [ Google Scholar ]
  5. Chen AC, Arany PR, Huang YY, Tomkinson EM, Sharma SK, Kharkwal GB, Saleem T, Mooney D, Yull FE, Blackwell TS, Hamblin MR. Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS ONE. 2011;15:e22453. doi: 10.1371/journal.pone.0022453.  [DOI ] [ Article ọ bụla PMC ] [ PubMed ] [ Google Scholar ]
  6. Huang YY, Chen AC, Carroll JD, Hamblin MR. Biphasic dose response in low level light therapy. Dose Response. 2009;15:358–383. doi: 10.2203/dose-response.09-027.Hamblin.  [DOI ] [ Article ọ bụla PMC ] [ PubMed ] [ Google Scholar ]
  7. Brosseau L, Welch V, Wells G, DeBie R, Gam A, Harman K, Morin M, Shea B, Tugwell P. Nke ihe ezu nwere ike laser (Classes I, II na III) maara n'ime osteoarthritis. Cochrane Database Syst Rev. 2004;15 doi: 10.1002/14651858.CD002046.pub2. CD002046.  [DOI ] [ PubMed ] [ Google Scholar ]
  8. Bjordal JM, Bogen B, Lopes-Martins RA, Klovning A. E lebe Cochrane Reviews n'asụsụ kontroversialị gbasara? Anaedo sensitivity analysis maka protocoli ọzọ Systematic Cochrane Review nke low-level laser therapy n'ime osteoarthritis. Photomed Laser Surg. 2005;15:453–458. doi: 10.1089/pho.2005.23.453.  [DOI ] [ PubMed ] [ Google Scholar ]
  9. Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese WA, Smotrich MH, Hamblin MR. Low-level laser therapy nke arthritis zymosan-ezu n'okpuru rat: mkpa anya nke illumination time. Lasers Surg Med. 2007;15:543–550. doi: 10.1002/lsm.20516.  [DOI ] [ Article ọ bụla PMC ] [ PubMed ] [ Google Scholar ]
  10. da Rosa AS, dos Santos AF, da Silva MM, Facco GG, Perreira DM, Alves AC, Leal Junior EC, de Carvalho Pde T. Akara ọdịnaya ndeihe laser n'ime mmiri 660 na 808 nm n'akwụkwọ mmehie ọfùfù osteoarthritis. Photochem Photobiol. 2012;15:161–166. doi: 10.1111/j.1751-1097.2011.01032.x.  [DOI ] [ PubMed ] [ Google Scholar ]
  11. Cidral-Filho FJ, Mazzardo-Martins L, Martins DF, Santos AR. Therapies diode ahụ maka akpụra analgesia n'akwụkwọ mmehie ọfùfù mouse n'ime mmehie ọfùfù postoperative n'ezuaka peripheral opioid receptors na L-arginine/nitric oxide pathway. Lasers Med Sci. 2013. Epub ahead of print.  [DOI ] [ PubMed ]
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