Ka taea e te aratohu te whakarongo i te raupapa?

Apr 15, 2025

Ka taea e te aratohu te whakarongo i te raupapa?

By"Hamblin MR"[Kaiwhakapuaki]

PMCID: PMC3978432 PMID: 24286607

Taumatai

Ka nui ake te hokoaro hei whakaeke i te hunga tangata. He mea tuhinga hou ka tohe tonu ki te pai o nga rongoa anti-inflammatory, ko te taunga o nga pire kawe he mea mate haere. Ko te whakarongo i te raupapa (marama) paunu (LLLT) he ara matihiko kē, kei whea i te mōhiotanga o te whakarongo i te raupapa, me etahi tuhinga pai rawa mo te pai o te mahi i roto i te raupapa. I tenei nuinga o Arthritis Research & Therapy , Alves me ōna hoa kaimahi i whakamahia te ratuhiwhiwhinga rākau ki te mōhiohanga o te urutā papaināki i roto i ngā huanga matua hei whakamatau i te LLLT 810-nm. Ko tētahi pūnaha tuatahi o te LLLT i whakauru whakatika ki ngā whakapakoko ā-wāhine me ngā kaiwhakaaro whakapakoko i muri i te 24 heke. Ko te wā katoa iti ake o te ra o te huringa nui ake i te wā katoa nui. Heoi, ko te mahi nui ake e hiahiatia ana kia whakahoki mai ai te patai i runga i te whakautu.

Taumatai

I tēnei take o Arthritis Research & Therapy , Alves me ōna hoa kaimahi [ 1] i whakaritea he rangahau mōhiohanga paihere i whakamahia te miro mokemoke nei ki te waewae kiore hei whakamana i ngā painga nui i runga i te urutā i roto i tētahi momo kararehe mō te urutā papaināki. Tētahi iwa atu i ngā rua tekau o ngā tangata i te Wīwīia e noho ana i tētahi whenua o te urutā papaināki i a rātau ao mārama, me te toitūnga 80% i ērā e tuohu ana i runga i te 75 tau [ 2]. Te whai wāhi i ngā rongoā pāwera (acetaminophen), ngā rongoā non-steroidal anti-inflammatory (NSAIDs) (ibuprofen me te diclofenac), ā, ko ngā tohenga COX2 (Celebrex, Pfizer Inc., New York, NY, USA), engari he nui ngā uiui o ēnei rongoā, pērā i te kōpūtahi gut hei tae atu ki ngā NSAIDs me te mate pakipaki manawa hei tae atu ki ngā tohenga COX2 [ 3]. Ko te rongoā miro (mihini) matua wehi iti (LLLT) tētahi huarahi e whai ake nei i ngā momo mate e hiahiatia ana ki te whakaiti whenu me te mate, te whakawātea i te haere pai, me te whakamau i te mate whenu i muri i te mate rānei, i te mate rourou rānei [ 4]. Kua kitea ngā fotonā red rānei me te near-infrared i roto i te cytochrome c oxidase (unit IV o te kaiwhakaohooho mitokondria), nā reira i whai take mai ai te kaiwhakaohooho mitokondria me te whakahaere i te ATP, ā, i whakaritea ai ngā huarahi whakahoki e whakahaere ana i ngā pūtau whakapūmau, nitric oxide, me te cyclic AMP, e kawe ana ki te whakahoahoa o ētahi transcription factors [ 5]. Nō te nui o ngā rautaki kua tirohia ngā pūtake whakaiti matekai o LLLT, ā, kua whakaatuhia ngā iti iho i te whitiwhiti whenua ki roto i ēnei momo mate maha, ā, kua whakaatu hoki i ngā iti iho i ēnei pūtau whakaiti, pērā i ngā ILs me te TNF-α. He maha ngā kairangahau i whakaatu he uara rua hangarua o te take whakamahere e mahi nei i roto i te LLLT, ā, ka noho hē ai tēnei, ka hoki whakamuri i te nui o te manuka ki te wā e tuku ana i te manuka (hua o te mana), ka hoki whakamuri hoki i te pai o te LLLT i waenganui i ngā take iti [ 6]. Kua whakamahi tonu a LLLT i roto i ngā raruraru kikokiko mō ētahi tau, engari ko ia tonu hei mea whakawhirinaki. Ki te whakaaetanga o te whakarongo Cochrane [ 7] kī ake ngā whakaraupapa me ngā hua e rūnaki ana, ko te whakatau i muri i a Bjordal me ōna hoa i whakaae he 'kāore te whakatau o te whakamātau Cochrane i te tūpono, nō reira i te tūponotanga. Ko te whakamātau anuenue tuatahi i āwhina ki ngā whakamātau kāore i whakauru, ko te mahi i ngā paerewa kua ngaro i muri, me ngā whakataurite i waho i te pūtanga i runga i ngā take iti, ka kitea he whakarite me ngā hua nui i roto i te whakaaetanga mo LLLT noa iho mo te mate urupa’ [ 8]. Ko tēnei korerorapu i roto i ngā tuhinga he tohu he waehanga nui rawa te mahi e hia nei, e anga atu ana ki ngā whakamātau kararehe, ngā whakamātau pūnaha, me ngā whakamātau whaihua, ka mutu ka whiwhi LLLT i te whakaaetanga hei rongoā tika.

Ko Alves me ōna hoa [ 1] whakamahia ngā momo kōrero pūtaiao mō te mate uruwhenua, i ahi ai te papainā ki roto i te huataki o te hokai, ka whakapēhea e ia te kareti, ko tēnā te take o te hāpai raruraru. I whiwhi ngā hokomahi i tētahi taipu anake o te 4 J o te huihuinga mai i te raeti 808-nm ki runga i ngā taha mataki me te taha kotahi o te hokai, e tuku ana i te 50 rānei 100 mW, ka whakaohoia ngā hokai i muri i te 24 wiki. Kua kitea e ngā kaiwhakarite he iti iho ngā wheako raruraru i roto i te wai mō te matenga o te whakawhanake i ngā momo kōwhiringa katoa, engari he nui ake te iti iho i ngā macrophages i te taipu 50-mW. Kua kitea he iti iho i ngā IL-1β me ngā IL-6 mRNA, ko te 50 mW e pai rawa nei i te 100 mW, ā, kua kitea he nui ake te iti iho i te TNF-α i te taipu 100 mW. Kua whakaaro ngā kaiwhakarite he mea nui rawa te waehanga tuarua hei whakatupu i te wā e taki ana i te taipu huihuinga e rua nei i te kaha, ka whakaae tonu he mea pai tēnei i te whakamahi o te raeti 50-mW, ahakoa tētahi rangahau i mua ka tirohia te mate uruwhenua i whakapāngia e te zymosan i roto i te hokai o te hokai [ 9] me he whakamātau i te mea ka nui ake te pai o te wā mōhuhu. I mua atu i tēnei mahi mai i tēnei rōpū [ 10] kua whakaatuhia he mea ko te RRTK i te rautaki tuatahi nei, i nui ake ai te angiogenesis me te nui o te epitemu kotiate ahakoa i iti ake ai te fibrosis i roto i te huatau. Ko ēnei hua he whakamana tuarua mō te whakamahi i te RRTK (āhua inoi-ā-waho e pā ana ki ngā huatau) hei rongoā mō te osteoarthritis. Nāheko, me whakapae he mea kaore i te whakangungu i te raraunga, engari he raraunga moemoeā noa iho, kāore i te raraunga hinengaro mō ngā mate tangata, me ngā whakamātau atu hei whakaaturanga i ngā painga o te RRTK i roto i te osteoarthritis. Nei pea ko te take ka whai painga anō te RRTK, ā, ka whai oranga mai i tana pūtake ki te mahi i runga i ngā herenga, ka iti ake te whakahaere whenu me te whakawea i ngā rarangi opioid matua [ 11].

Pīkau

IL: Interleukin; LLLT: Low-level laser (light) therapy; NSAID: Non-steroidal anti-inflammatory drug; TNF-α: Tumor necrosis factor-alpha.

Paheko

Ko te kaiwhakapuare i whakaatu mai he kore hiahia ki te whai i ngā huarahi kē.

Tirohia te rangahau pūnaha e pā ana ki a Alves et al . http://arthritis-research.com/content/15/5/R116

Nga Whakahoki

Te rangahau i roto i te wāhi whakamātau a te kaiwhakapuare e tautoko nei nā ngā Pūtea Hauora o te Motu Rōpū Hauora grant R01AI050875.

Nga Tuhipoka

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